import Foundation import OdeInt import RealModule public enum ECGSyn { public struct Parameters { /// The ECG amplitude in mV. let range: (Double, Double) = (-0.4, 1.4) /// Amplitude of the noise. let aNoise: Double = 0.0 /// The angle of each attractor (P, Q, R, S, T) around the limit cycle, in radians. let theta: [Double] = [-70, -15, 0, 15, 100].map { $0 * .pi / 180 } /// The position of attractors (P, Q, R, S, T) above or below the z=0 plane. let a: [Double] = [1.2, -5, 30, -7.5, 0.75] /// Widths of the attractors (P, Q, R, S, T). let b: [Double] = [0.25, 0.1, 0.1, 0.1, 0.4] } public static func generate(params: Parameters, rrSeries: RRSeries) -> [Double] { var rng = rrSeries.rng let srInternal = rrSeries.timeParameters.srInternal // adjust extrema parameters for mean heart rate let hrFact = sqrt(rrSeries.timeParameters.hrMean / 60.0) let hrFactSqrt = sqrt(hrFact) let ai = params.a let bi = params.b.map { $0 * hrFact } let ti = zip([hrFactSqrt, hrFact, 1, hrFact, hrFactSqrt], params.theta).map(*) let fhi = rrSeries.rrParamaters.fhi let nt = rrSeries.count let dt = 1.0 / Double(srInternal) let ts = (0 ..< nt).map { Double($0) * dt } let x0 = SIMD3(1.0, 0.0, 0.04) let result = SIMD3.integrate(over: ts, y0: x0, tol: 1e-6) { x, t in let ta = atan2(x[1], x[0]) let r0 = 1.0 let a0 = 1.0 - sqrt(x[0] * x[0] + x[1] * x[1]) / r0 let w0 = 2 * .pi / rrSeries.valueAt(t) let zbase = 0.005 * sin(2 * .pi * fhi * t) var dxdt = SIMD3(a0 * x[0] - w0 * x[1], a0 * x[1] + w0 * x[0], 0.0) for i in 0 ..< ti.count { let dt = remainder(ta - ti[i], 2 * .pi) dxdt[2] += -ai[i] * dt * exp(-0.5 * (dt * dt) / (bi[i] * bi[i])) } dxdt[2] += -1.0 * (x[2] - zbase) return dxdt } // extract z and downsample to ECG sampling frequency let qstep = srInternal / rrSeries.timeParameters.srEcg var zresult = stride(from: 0, to: nt, by: qstep).map { result[$0][2] } let (zmin, zmax) = zresult.minAndMax()! let zrange = zmax - zmin // Scale signal between -0.4 and 1.2 mV // add uniformly distributed measurement noise for i in 0 ..< zresult.count { zresult[i] = (params.range.1 - params.range.0) * (zresult[i] - zmin) / zrange + params.range.0 zresult[i] += params.aNoise * (2.0 * rng.nextDouble() - 1.0) } return zresult } }